Researchers in Malaysia
Micropollutant and Pathogen in Water Research Group (WaterµPath) consists of seven (7) group members from various academic background and is led by Dr Marfiah Ab.Wahid from the Faculty of Civil Engineering, UiTM Shah Alam. Research interest of this group is on the monitoring and modeling of micropollutants including residual Personal Pharmaceutical Care Products (PPCPs), antibiotics, residual drugs and pathogenic bacteria in water environment. Our research on pathogenic bacteria is mainly focusing on their antibiotic resistance and survival in water and wastewater. Modeling of the dynamics and transport of residual micro pollutant and pathogens in river water is done using DEFLT software, whereas modeling of wastewater treatment plant is done using Computational Fluid Dynamics (CFD) software. In order to reduce the risk to human and ecological health in water environment, several different treatment technologies are being tested in a laboratory scale including UV, membrane and Advanced Oxidation Processes (AOPs).
We are seeking collaborators with experience and interest in developing technology for the detection, measurement, treatment and modeling of micropollutant and pathogen in water environment.
We have designed and built prototype for on-site detector of pathogenic bacteria in water environment. Therefore, we are also seeking industries interested in helping us commercialise our prototype equipment.
Dr Marfiah Ab.Wahid
Micropollutant and Pathogen in Water Research Group
Faculty of Civil Engineering, Universiti Teknologi MARA
40450 Shah Alam,Selangor
Website – https://fka.uitm.edu.my/v2/
The need to understand and manipulate chemical and biological systems at the micro-molecular level to obtain the desired macroscopic specifications calls for the development of multi-scale distributed approaches to model physical systems. Our research is motivated by the use of interesting mathematical ideas to solve important problems in chemical and biochemical engineering, and the main thrust of our work is fundamental. Our primary focus is in the advancement and application of population balances – a broad collective wealth of knowledge which deals with the evolutionary aspects of dispersed phase systems, both in time and perhaps also in space. On-going projects revolve around the application areas of biomass depolymerization, complex biomass polymer fermentation, distributed emulsification dynamics and advanced control of biomedical devices.
We especially welcome potential collaborators in the field of lignocellulosic hydrolysis and fermentation who can provide us with distributed experimental data. We are also keen to work with experimentalists in protein engineering who might be interested in exploring new computational methods. For more information on our research findings, please refer to the google scholar website below.
Affiliation: Chemical Engineering Discipline, School of Engineering,
Monash University Malaysia.
Dr. Ho Yong Kuen,
Building 5, Level 5, Room 38 (5-5-38)
Monash University Malaysia
Jalan Lagoon Selatan
47500 Bandar Sunway
Selangor Darul Ehsan
Website – https://www.facebook.com/yongkuenho/
Google Scholar Website – https://scholar.google.com/citations?user=m2tAJC4AAAAJ&hl=en
We are a group of chemists, engineers and physicists working in the field of organic electronics. Our mission is to bring organic electronics from the lab to pre- commercialisation stage. Our vision is to create a more environmentally friendly electronics at low cost and at the same time to encourage techno-entrepreneurship in Malaysia.
Our research focuses on efficiency and performance of the materials and devices. By studying the charge transport, interfacial barriers, energy levels of organic semiconducting materials, exciton confinement, exciton dissociation, synthesis of various novel organic semiconducting materials, molecular modelling and correlation between molecular structure and device properties, we hope to achieve devices with very high performance. We fabricate various devices such as organic field effect transistors, organic phototransistors, organic light emitting diode, organic photovoltaic and smart organic electronics. We also actively patent our new findings.
We are seeking collaborators with experience in organic synthesis, device modelling and integration of different devices into user-friendly products. We are also seeking industries which are interested to bring such technology into commercial world.
Dr. Woon Kai Lin:
E: [email protected] T: +603-79674287 A216, Department of Physics
Faculty of Science
50603, Kuala Lumpur
Dr. Woon’s Scientific Malaysian profile: http://www. scientificmalaysian.com/members/kailin/
Dr. Woon’s website: http://fizik.um.edu.my/wkl/
Neuroscience is one of the escalating and most fascinating endeavours of biology research today. Neuroscience research has advanced knowledge on how a brain functions, how a neurone behaves and how damaged neuronal networks may lead to various neurological disorders. In Universiti Putra Malaysia (UPM), neuroscience research is now one of the priority niche areas. Besides, steps have been taken to gather both the scientists and clinicians who venture in the field by pooling resources and practicing knowledge sharing. Our research group, known as NeuroBiology and Genetics Group (NBGG), is interested in unraveling the role of genetic factors and molecular networks that regulate the development and function of the mammalian brain. Our group place a great emphasis in three main areas of research; (1) neurological disorders, (2) non-coding RNA roles in brain development and function and (3) technology transfer and development on gene delivery platform.
NBGG is involved in deciphering the genetic landscape leading to disrupted molecular pathways and processes responsible for Down syndrome pathology (trisomy 21) and associated disorders (defective neurogenesis and intellectual disability). With limited access to Down syndrome patient tissues and the lack of comprehensive investigations at the molecular level, we have employed Ts1Cje, a mouse model for Down syndrome to facilitate genetic dissection of the learning, behavioural and neurological abnormalities in Down syndrome. In collaboration with Professor Hamish Scott from the University of Adelaide, South Australia, we profile gene expression pattern at various regions of the Down syndrome brain at different stages of development. Spatiotemporal comparisons of gene expression profiles between the normal and Down syndrome brains provide a great genetic overview that may provide clues on what has gone wrong in the Down syndrome brain. In addition to the brain development, our interest also extends to identifying the molecular mechanism responsible for hypotonia (decrease in muscle tone), a cardinal feature, in Down syndrome. Our group plans to generate a comprehensive catalogue of molecular and cellular properties that affect locomotor functions and vesicle recycling mechanism at the neuromuscular junction of the Ts1cje mouse model. The ultimate aim of our research is to determine the effect of the additional gene dosage in the trisomic model. In the long term, NBGG aims to develop molecular therapies that may improve the quality of life among Down syndrome patients.
A different branch of NBGG research is to understand the role of non-coding RNAs in regulating the development of the mammalian brain. Our group has a special interest in characterising the molecular role of a few novel microRNAs (miRNAs), that are found to be expressed throughout embryonic development especially in the brain. miRNAs are short RNA sequences with 18-24nt in length. miRNAs target mainly at the 3’ UTR of mRNA to either repress translation processes or promote mRNA degradation. In both cases, miRNAs will influence the level of protein synthesis. When the phenomenon happens at a global scale, changes of the amount of proteins synthesised may affect the phenotypic characteristics of the cell. In the context of a developing brain, miRNAs may play a crucial role in regulating neurogenesis, neuronal differentiation and function. To dissect the molecular role of these novel miRNAs, NBGG plans to use various techniques such as in situ hybridisation, stemloop-RT-qPCR, overexpression studies, Western blotting and luciferase assay analysis in various models such as mouse embryonic stem cells, differentiated neurones, primary neuronal cultures and brain sections.
To complement our efforts in elucidating the role of various candidate genes and miRNAs in brain development or function, our group is in the midst of establishing a “super electroporator” platform for the delivery of charged particles into specific regions of the mouse brain. Charged particles such as DNA constructs with Green Fluorescent Protein (GFP) as traceable gene reporter system have been established in our laboratory and are ready to be electroporated into the developing mouse brain in utero. The platform will facilitate us to trace the formation of defective migratory routes of neurones in the Down syndrome brain in the presence or absence of selected candidate trisomic genes. The platform also enables us to study the function of novel miRNAs in a spatiotemporal manner throughout the development and maturation of the brain.
Our group also works with clinicians to screen for aberrations of selected genes in Parkinson’s disease and infantile spastic patients. In addition, we look forward to any queries regarding our research projects and welcome any potential collaborators to work on the following extended research topics:
a) Advancement of the ‘super electroporator’ platform and its applications in in utero, in vitro as well as in vivo delivery of charged particles.
b) Identification and characterisation of natural products that may improve the learning and memory capability in Ts1Cje mouse model.
c) Exploration of the role of novel miRNAs in early embryo development.
d) Characterisation of candidate noncoding RNAs in human Down syndrome induced pluripotent stem cell (iPSC)-derived neurones.
e) Elucidation of long noncoding RNAs roles in gene expression regulation in the mammalian brain via bioinformatics and genomics approaches.
Dr. Michael KH Ling:
[email protected] +603-89472564
Dr Ling’s Scientific Malaysian profile: https://www.scientificmalaysian.com/scimy/members/michaelling/
Dr. Pike-See Cheah:
[email protected] +603-89472355
Dr Cheah’s Scientific Malaysian profile: https://www.scientificmalaysian.com/scimy/members/pikesee/
Furley Group of Companies started as a humble food ingredient trader comprising of two individuals. As the customer base grew, so did the demands for expertise in formulations for nutraceutical powders and beverages. To cater to this demand, Furley Bioextracts was formed in 2008. Furley Bioextracts has strong roots in the nutraceutical beverages and our fortes are in fruit juice concentrates and powder blending. With assistance from the Malaysian government, Biotech Corp awarded Furley Bioextracts the BioNexus status as recognition of Furley Bioextracts’ involvement in biotechnology. This helped Furley establish itself as a Biotechnological industry player.
Not only does Furley do formulations, we also do manufacturing and establishment of quality systems beyond that of ISO 22000 for selected food products. This is to ensure consistency and safety of food products manufactured by Furley. Furley has two manufacturing sites which segregate manufacturing based on ingredient and customer requirements, be it environmental control, to specific laboratory or testing for quality control. Our manufacturing certifications include BioNexus Status, GMP, HACCP JAS-ANZ and Traditional cGMP, making us export ready. We are also working towards ISO 22000 and FSSC 22000.
Our research and development team comprises of 6 members with a majority of the members holding postgraduate degrees. Marketing and Sales comprises of 5 members and manufacturing comprises of 25 – 50 staff. This makes Furley Bioextracts a relatively tight knit team. Having decades of experience onboard, we are the preferred premium nutraceutical house working with food industry giants, from Swiss multinationals to small medium enterprises. We constantly strive to produce innovative premium products which have set us apart from our competitors.
In short, a successful formulation is not a matter of combining ingredients from a base formulation. A variety of factors has to be considered in order to achieve commercial viability. Some important issues to be considered include supply chain management, ingredient reactions, stability, sensory, legislation and product shelf life. We have collaborations with Forestry Research Institute Malaysia (FRIM) since late 2006 in the commercialization of their standardized herbal extracts. This collaboration has been given numerous awards (Geneva & ITEX), with its winning products ranging from soft serve ice-cream, beverages to cookies. Our latest milestone is the cultivation, processing and supply of mangosteen and local Malaysian herbal derivatives and extracts.
We are seeking to collaborate with institutions for the following purposes:
1) To conduct research they feel is feasible in the context of beverages or powders. We will provide assistance with commercialization of such products.
2) To standardize methods of supplying mangosteen and selected Malaysian herbs.
3) To conduct quality control processes for mangosteen and selected Malaysian herbs.
4) To conduct in-house quality control systems for manufacturing. We wish to receive product knowledge, marketable product, market exposure and recognition from the collaboration.
In return, the institute/scientist will receive:
i) Acknowledgement where deserved.
iii) Commercial prototypes.
iv) An advantageous edge in competitions for Awards e.g. Geneva or ITEX
v) An export ready product
vi) Satisfaction of consuming their research literally.
Depending on the feasibility of the end collaboration it may conclude with just a prototype (pure learning exercise) or a full commercialization process. This varies according to how the respective institution operates according to their terms and conditions. We are flexible and look forward to input from potential collaborators.
Scientific Malaysian Profile:
Website – http://www.furleybioextracts.com.my/